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BBR ameliorates diabetic pulmonary injury BBR, as the main active component of Coptis chinensis inflorescence extract, reduces the expression of inflammatory cytokines by activating the AMPK/NEU1 pathway and inhibiting the TGFβ1/Smad pathway, reverses EMT and reduces pathological damage in lung tissue (Wang et al., 2023)

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Additionally, atherosclerotic plaques can be destabilized by systemic inflammatory response which happens simultaneously with pro-inflammatory and pro-oxidative effects of SARS-CoV-2, thereby giving rise to acute coronary syndrome and ischemic heart disease among COVID-19 patients